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Dual‐Pore Mesoporous Carbon@Silica Composite Core–Shell Nanospheres for Multidrug Delivery
Author(s) -
Fang Yin,
Zheng Gengfeng,
Yang Jianping,
Tang Haosha,
Zhang Yafeng,
Kong Biao,
Lv Yingying,
Xu Congjian,
Asiri Abdullah M.,
Zi Jian,
Zhang Fan,
Zhao Dongyuan
Publication year - 2014
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201402002
Subject(s) - mesoporous material , materials science , composite number , mesoporous silica , nanotechnology , paclitaxel , drug delivery , chemical engineering , carbon fibers , mesoporous organosilica , core (optical fiber) , shell (structure) , chemistry , organic chemistry , cancer , composite material , catalysis , medicine , engineering
Monodispersed mesoporous phenolic polymer nanospheres with uniform diameters were prepared and used as the core for the further growth of core–shell mesoporous nanorattles. The hierarchical mesoporous nanospheres have a uniform diameter of 200 nm and dual‐ordered mesopores of 3.1 and 5.8 nm. The hierarchical mesostructure and amphiphilicity of the hydrophobic carbon cores and hydrophilic silica shells lead to distinct benefits in multidrug combination therapy with cisplatin and paclitaxel for the treatment of human ovarian cancer, even drug‐resistant strains.