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Aza[6]helicene Platinum Complexes: Chirality Control of cis–trans Isomerism
Author(s) -
Mendola Daniele,
Saleh Nidal,
Vanthuyne Nicolas,
Roussel Christian,
Toupet Loïc,
Castiglione Franca,
Caronna Tullio,
Mele Andrea,
Crassous Jeanne
Publication year - 2014
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201401004
Subject(s) - helicene , enantiopure drug , chirality (physics) , chemistry , reactivity (psychology) , stereochemistry , platinum , enantioselective synthesis , molecule , organic chemistry , catalysis , medicine , chiral symmetry breaking , physics , alternative medicine , pathology , quantum mechanics , quark , nambu–jona lasinio model
It was serendipitously observed that cis ‐[PtCl 2 (NCEt)PPh 3 ] reacted differently with either racemic or enantiopure 4‐aza[6]helicene, giving respectively cis (racemic) and trans (enantiopure) [Pt II Cl 2 (4‐aza[6]helicene)PPh 3 ] complexes. This unexpected reactivity is explained through a dynamic process (crystallization‐induced diastereoselective transformation) and enables a new aspect of reactivity in chiral transition‐metal complexes to be addressed.