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Direct Allylation of In Situ Generated Aldehyde Acyl Anions by Synergistic NHC and Palladium Catalysis
Author(s) -
Ahire Milind M.,
Mhaske Santosh B.
Publication year - 2014
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201400623
Subject(s) - aldehyde , chemistry , catalysis , regioselectivity , allylic rearrangement , palladium , in situ , synergistic catalysis , combinatorial chemistry , organic chemistry
The direct regioselective allylation of in situ generated aldehyde acyl anions has been achieved by synergistic NHC and Pd catalysis. It provides an efficient access to valuable β,γ‐unsaturated ketones under mild reaction conditions starting from easily accessible allylic carbonates and aldehydes without any preactivation. The synergistic catalysis method demonstrated herein adds a new dimension to the area of metal‐mediated C allylation.