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Silver‐Catalyzed Oxidative Activation of Benzylic CH Bonds for the Synthesis of Difluoromethylated Arenes
Author(s) -
Xu Peng,
Guo Shuo,
Wang Liyan,
Tang Pingping
Publication year - 2014
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201400225
Subject(s) - selectfluor , catalysis , reagent , chemistry , fluorine , aqueous solution , combinatorial chemistry , organic chemistry
A mild and catalytic method to form difluoromethylated arenes through the activation of benzylic CH bonds has been developed. Utilizing AgNO 3 as the catalyst, various arenes with diverse functional groups undergo activation/fluorination of benzylic CH bonds with commercially available Selectfluor reagent as a source of fluorine in aqueous solution. The reaction is operationally simple and amenable to gram‐scale synthesis.