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Palladium‐Catalyzed Heck‐Type Cross‐Couplings of Unactivated Alkyl Iodides
Author(s) -
McMahon Caitlin M.,
Alexanian Erik J.
Publication year - 2014
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201311323
Subject(s) - alkyl , chemistry , palladium , catalysis , nucleophile , intermolecular force , heck reaction , combinatorial chemistry , organic chemistry , molecule
A palladium‐catalyzed, intermolecular Heck‐type coupling of alkyl iodides and alkenes is described. This process is successful with a variety of primary and secondary unactivated alkyl iodides as reaction partners, including those with hydrogen atoms in the β position. The mild catalytic conditions enable intermolecular CC bond formations with a diverse set of alkyl iodides and alkenes, including substrates containing base‐ or nucleophile‐sensitive functionality.