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Sequential Intra‐Intercellular Nanoparticle Delivery System for Deep Tumor Penetration
Author(s) -
Ju Caoyun,
Mo Ran,
Xue Jingwei,
Zhang Lei,
Zhao Zekai,
Xue Lingjing,
Ping Qineng,
Zhang Can
Publication year - 2014
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201311227
Subject(s) - nanogel , swelling , penetration (warfare) , nanoparticle , biophysics , cytotoxicity , chemistry , intracellular , bovine serum albumin , chitosan , polyelectrolyte , drug delivery , nanotechnology , materials science , polymer , biochemistry , in vitro , organic chemistry , biology , operations research , engineering , composite material
To achieve deep tumor penetration of large‐sized nanoparticles (NPs), we have developed a reversible swelling–shrinking nanogel in response to pH variation for a sequential intra‐intercellular NP delivery. The nanogel had a crosslinked polyelectrolyte core, consisting of N ‐lysinal‐ N ′‐succinyl chitosan and poly( N ‐isopropylacrylamide), and a crosslinked bovine serum albumin shell, which was able to swell in an acidic environment and shrink back under neutral conditions. The swelling resulted in a rapid release of the encapsulated chemotherapeutics in the cancer cells for efficient cytotoxicity. After being liberated from the dead cells, the contractive nanogel could infect neighboring cancer cells closer to the center of the tumor tissue.