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Copper‐Catalyzed Electrophilic Amination of Heteroarenes and Arenes by CH Zincation
Author(s) -
McDonald Stacey L.,
Hendrick Charles E.,
Wang Qiu
Publication year - 2014
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201311029
Subject(s) - electrophilic amination , amination , chemistry , electrophile , catalysis , combinatorial chemistry , organic chemistry , functional group , polymer
Direct amination of heteroarenes and arenes has been achieved in a one‐pot CH zincation/copper‐catalyzed electrophilic amination procedure. This amination method provides an efficient and rapid approach to access a diverse range of heteroaromatic and aromatic amines including those previously inaccessible using CH amination methods. The mild reaction conditions and good functional‐group compatibility demonstrate its great potential for the synthesis of important and complex amines.