Double Transfer of Chirality in Organocopper‐Mediated bis(Alkylating) Cycloisomerization of Enediynes | Zendy

Campolo Damien | Zendy; Arif Tanzeel | Zendy; Borie Cyril | Zendy; Mouysset Dominique | Zendy; Vanthuyne Nicolas | Zendy; Naubron JeanValère | Zendy; Bertrand Michèle P. | Zendy; Nechab Malek | Zendy

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Double Transfer of Chirality in Organocopper‐Mediated bis(Alkylating) Cycloisomerization of Enediynes

Author(s) -

Campolo Damien,

Arif Tanzeel,

Borie Cyril,

Mouysset Dominique,

Vanthuyne Nicolas,

Naubron JeanValère,

Bertrand Michèle P.,

Nechab Malek

Publication year - 2014

Publication title -

angewandte chemie

Language(s) - English

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.201310530

Subject(s) - cycloisomerization , chirality (physics) , enantiopure drug , enantioselective synthesis , chemistry , reagent , phenanthrenes , stereochemistry , combinatorial chemistry , organic chemistry , catalysis , physics , phenanthrene , chiral symmetry breaking , quantum mechanics , nambu–jona lasinio model , quark

An original synthesis of chiral benzofulvenes triggered by organocopper reagents is reported. These enantiopure products are available through a highly chemo‐, regio‐, diastereo‐, and enantioselective bis(alkylating) cycloisomerization process. A double chirality transfer (central‐to‐axial‐to‐central) is observed.

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