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A Synergistic Capture Strategy for Enhanced Detection and Elimination of Bacteria
Author(s) -
Li YongQiang,
Zhu Bowen,
Li Yuangang,
Leow Wan Ru,
Goh Rubayn,
Ma Bing,
Fong Eileen,
Tang Mark,
Chen Xiaodong
Publication year - 2014
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201310135
Subject(s) - bacteria , chemistry , substrate (aquarium) , nanotechnology , nanotopography , bacterial colony , pathogenic bacteria , combinatorial chemistry , materials science , biology , ecology , genetics
Despite the advanced detection and sterilization techniques available today, the sensitive diagnosis and complete elimination of bacterial infections remain a significant challenge. A strategy is reported for efficient bacterial capture (ca. 90 %) based on the synergistic effect of the nanotopography and surface chemistry of the substrate on bacterial attachment and adhesion. The outstanding bacterial‐capture capability of the functionalized nanostructured substrate enables rapid and highly sensitive bacterial detection down to trace concentrations of pathogenic bacteria (10 colony‐forming units mL −1 ). In addition, this synergistic biocapture substrate can be used for efficient bacterial elimination and shows great potential for clinical antibacterial applications.