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Enantioselective Palladium‐Catalyzed Insertion of α‐Aryl‐α‐diazoacetates into the OH Bonds of Phenols
Author(s) -
Xie XiuLan,
Zhu ShouFei,
Guo JunXia,
Cai Yan,
Zhou QiLin
Publication year - 2014
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201309820
Subject(s) - enantioselective synthesis , palladium , aryl , insertion reaction , catalysis , chemistry , phenols , yield (engineering) , combinatorial chemistry , medicinal chemistry , organic chemistry , materials science , alkyl , metallurgy
A palladium‐catalyzed asymmetric OH insertion reaction was developed. Palladium complexes with chiral spiro bisoxazoline ligands promoted the insertion of α‐aryl‐α‐diazoacetates into the OH bond of phenols with high yield and excellent enantioselectivity under mild reaction conditions. This palladium‐catalyzed asymmetric OH insertion reaction provided an efficient and highly enantioselective method for the preparation of synthetically useful optically active α‐aryl‐α‐aryloxyacetates.