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Dihydrobiphenylenes through Ruthenium‐Catalyzed [2+2+2] Cycloadditions of ortho ‐Alkenylarylacetylenes with Alkynes
Author(s) -
GarcíaRubín Silvia,
GonzálezRodríguez Carlos,
GarcíaYebra Cristina,
Varela Jesús A.,
Esteruelas Miguel A.,
Saá Carlos
Publication year - 2014
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201309496
Subject(s) - cycloaddition , ruthenium , catalysis , chemistry , combinatorial chemistry , medicinal chemistry , organic chemistry
A new synthetic route to dihydrobiphenylenes has been developed. The process involves a mild Ru II ‐catalyzed [2+2+2] dimerization of ortho ‐alkenylarylacetylenes or its more versatile variant, the Ru‐catalyzed [2+2+2] cycloaddition of ortho ‐ethynylstyrenes with alkynes. Mechanistic aspects of this [2+2+2] cycloaddition are discussed.
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