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Diphenylacetylene‐Linked Peptide Strands Induce Bidirectional β‐Sheet Formation
Author(s) -
Lingard Hannah,
Han Jeongmin T.,
Thompson Amber L.,
Leung Ivanhoe K. H.,
Scott Richard T. W.,
Thompson Sam,
Hamilton Andrew D.
Publication year - 2014
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201309353
Subject(s) - diphenylacetylene , beta sheet , chemistry , peptide , crystallography , stereochemistry , biochemistry , catalysis
Abstract In the search for synthetic mimics of protein secondary structures relevant to the mediation of protein–protein interactions, we have synthesized a series of tetrasubstituted diphenylacetylenes that display β‐sheet structures in two directions. Extensive X‐ray crystallographic and NMR solution phase studies are consistent with these proteomimetics adopting sheet structures, displaying both hydrophobic and hydrophilic amino acid side chains.