Palladium‐Catalyzed Oxidative Carbonylation of  N ‐Allylamines for the Synthesis of β‐Lactams | Zendy

Li Wu | Zendy; Liu Chao | Zendy; Zhang Heng | Zendy; Ye Keyin | Zendy; Zhang Guanghui | Zendy; Zhang Wangzheng | Zendy; Duan Zhengli | Zendy; You Shuli | Zendy; Lei Aiwen | Zendy

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Palladium‐Catalyzed Oxidative Carbonylation of N ‐Allylamines for the Synthesis of β‐Lactams

Author(s) -

Li Wu,

Liu Chao,

Zhang Heng,

Ye Keyin,

Zhang Guanghui,

Zhang Wangzheng,

Duan Zhengli,

You Shuli,

Lei Aiwen

Publication year - 2014

Publication title -

angewandte chemie

Language(s) - English

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.201309081

Subject(s) - carbonylation , palladium , catalysis , chemistry , oxidative phosphorylation , ring (chemistry) , methylene , lactam , organic chemistry , combinatorial chemistry , oxidative addition , medicinal chemistry , carbon monoxide , biochemistry

β‐Lactam scaffolds are considered to be ideal building blocks for the synthesis of nitrogen‐containing compounds. A new palladium‐catalyzed oxidative carbonylation of N ‐allylamines for the synthesis of α‐methylene‐β‐lactams is reported. DFT calculations suggest that the formation of β‐lactams via a four‐membered‐ring transition state is favorable.

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