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Palladium‐Catalyzed Oxidative Carbonylation of N ‐Allylamines for the Synthesis of β‐Lactams
Author(s) -
Li Wu,
Liu Chao,
Zhang Heng,
Ye Keyin,
Zhang Guanghui,
Zhang Wangzheng,
Duan Zhengli,
You Shuli,
Lei Aiwen
Publication year - 2014
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201309081
Subject(s) - carbonylation , palladium , catalysis , chemistry , oxidative phosphorylation , ring (chemistry) , methylene , lactam , organic chemistry , combinatorial chemistry , oxidative addition , medicinal chemistry , carbon monoxide , biochemistry
β‐Lactam scaffolds are considered to be ideal building blocks for the synthesis of nitrogen‐containing compounds. A new palladium‐catalyzed oxidative carbonylation of N ‐allylamines for the synthesis of α‐methylene‐β‐lactams is reported. DFT calculations suggest that the formation of β‐lactams via a four‐membered‐ring transition state is favorable.