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Controlled Trifluoromethylation Reactions of Alkynes through Visible‐Light Photoredox Catalysis
Author(s) -
Iqbal Naeem,
Jung Jaehun,
Park Sehyun,
Cho Eun Jin
Publication year - 2014
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201308735
Subject(s) - trifluoromethylation , alkyne , chemistry , photoredox catalysis , catalysis , reactivity (psychology) , photochemistry , solvent , selectivity , visible spectrum , combinatorial chemistry , organic chemistry , photocatalysis , materials science , trifluoromethyl , pathology , medicine , alkyl , alternative medicine , optoelectronics
The control of a reaction that can form multiple products is a highly attractive and challenging concept in synthetic chemistry. A set of valuable CF 3 ‐containing molecules, namely trifluoromethylated alkenyl iodides, alkenes, and alkynes, were selectively generated from alkynes and CF 3 I by environmentally benign and efficient visible‐light photoredox catalysis. Subtle differences in the combination of catalyst, base, and solvent enabled the control of reactivity and selectivity for the reaction between an alkyne and CF 3 I.