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Catalytic Enantioselective Oxidative Cross‐Coupling of Benzylic Ethers with Aldehydes
Author(s) -
Meng Zhilin,
Sun Shutao,
Yuan Huiqing,
Lou Hongxiang,
Liu Lei
Publication year - 2014
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201308701
Subject(s) - enantioselective synthesis , chemistry , nucleophile , catalysis , oxidative coupling of methane , oxidative phosphorylation , organic chemistry , coupling (piping) , combinatorial chemistry , materials science , metallurgy , biochemistry
The first one‐pot enantioselective oxidative coupling of cyclic benzylic ethers with aldehydes has been developed. A variety of benzylic ethers were transformed into the corresponding oxygen heterocycles with high enantioselectivity. Mechanistic experiments were conducted to determine the nature of the reaction intermediates. The application of this strategy to coupling reactions with other nucleophiles besides aldehydes was also explored.