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Stereospecific Nickel‐Catalyzed Cross‐Coupling Reactions of Alkyl Grignard Reagents and Identification of Selective Anti‐Breast‐Cancer Agents
Author(s) -
Yonova Ivelina M.,
Johnson A. George,
Osborne Charlotte A.,
Moore Curtis E.,
Morrissette Naomi S.,
Jarvo Elizabeth R.
Publication year - 2014
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201308666
Subject(s) - stereospecificity , reagent , alkyl , catalysis , aryl , chemistry , nickel , coupling reaction , combinatorial chemistry , organic chemistry
Alkyl Grignard reagents that contain β‐hydrogen atoms were used in a stereospecific nickel‐catalyzed cross‐coupling reaction to form C(sp 3 )C(sp 3 ) bonds. Aryl Grignard reagents were also utilized to synthesize 1,1‐diarylalkanes. Several compounds synthesized by this method exhibited selective inhibition of proliferation of MCF‐7 breast cancer cells.