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Aqueous Anion Receptors through Reduction of Subcomponent Self‐Assembled Structures
Author(s) -
Mosquera Jesús,
Zarra Salvatore,
Nitschke Jonathan R.
Publication year - 2014
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201308117
Subject(s) - chemistry , pyranine , aqueous solution , fluorescence , molecule , covalent bond , metal ions in aqueous solution , fluorescence spectroscopy , combinatorial chemistry , nuclear magnetic resonance spectroscopy , ion , organic chemistry , biochemistry , physics , quantum mechanics , membrane
Abstract To prepare new functional covalent architectures that are difficult to synthesize using conventional organic methods, we developed a strategy that employs metal–organic assemblies as precursors, which are then reduced and demetalated. The host–guest chemistry of the larger receptor thus prepared was studied using NMR spectroscopy and fluorescence experiments. This host was observed to strongly bind aromatic polyanions in water, including the fluorescent dye molecule pyranine with nanomolar affinity, thus allowing for the design of an indicator‐displacement assay.