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Thread Insertion of a Bis(dipyridophenazine) Diruthenium Complex into the DNA Double Helix by the Extrusion of AT Base Pairs and Cross‐Linking of DNA Duplexes
Author(s) -
Boer D. Roeland,
Wu Lisha,
Lincoln Per,
Coll Miquel
Publication year - 2014
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201308070
Subject(s) - moiety , ruthenium , base pair , chemistry , dna , stereochemistry , oligonucleotide , a dna , extrusion , molecule , crystallography , materials science , organic chemistry , metallurgy , biochemistry , catalysis
The crystal structure of the Δ,Δ enantiomer of the binuclear “light‐switch” ruthenium complex [μ‐(11,11′‐bidppz)(1,10‐phenanthroline) 4 Ru 2 ] 4+ bound to the oligonucleotide d(CGTACG) shows that one dppz moiety of the dumbbell‐like compound inserts into the DNA stack through the extrusion of an AT base pair. The second dppz moiety recruits a neighboring DNA molecule, and the complex thus cross‐links two adjacent duplexes by bridging their major grooves.