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Rhodium‐Catalyzed Ketone Methylation Using Methanol Under Mild Conditions: Formation of α‐Branched Products
Author(s) -
Chan Louis K. M.,
Poole Darren L.,
Shen Di,
Healy Mark P.,
Donohoe Timothy J.
Publication year - 2014
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201307950
Subject(s) - rhodium , iridium , catalysis , methanol , chemistry , alkylation , ketone , methylation , organic chemistry , combinatorial chemistry , biochemistry , gene
The rhodium‐catalyzed methylation of ketones has been accomplished using methanol as the methylating agent and the hydrogen‐borrowing method. The sequence is notable for the relatively low temperatures that are required and for the ability of the reaction system to form α‐branched products with ease. Doubly alkylated ketones can be prepared from methyl ketones and two different alcohols by using a sequential one‐pot iridium‐ and rhodium‐catalyzed process.