Copper‐Catalyzed Reduction of Alkyl Triflates and Iodides: An Efficient Method for the Deoxygenation of Primary and Secondary Alcohols | Zendy

Dang Hester | Zendy; Cox Nick | Zendy; Lalic Gojko | Zendy

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Copper‐Catalyzed Reduction of Alkyl Triflates and Iodides: An Efficient Method for the Deoxygenation of Primary and Secondary Alcohols

Author(s) -

Dang Hester,

Cox Nick,

Lalic Gojko

Publication year - 2014

Publication title -

angewandte chemie

Language(s) - English

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.201307697

Subject(s) - deoxygenation , chemistry , alkyl , catalysis , primary (astronomy) , organic chemistry , combinatorial chemistry , reduction (mathematics) , physics , astronomy , geometry , mathematics

We describe an effective method for catalytic reduction of 1° alkyl sulfonates, and 1° and 2° iodides in the presence of a wide range of functional groups. This Cu‐catalyzed reaction provides a means for the effective deoxygenation of alcohols, as demonstrated by the highly selective reduction of 1° alcohols using a triflation/reduction sequence. A preliminary study of the reaction mechanism suggests that the reduction does not involve free‐radical intermediates.

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