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Overcoming the Unexpected Functional Inversion of a PqsR Antagonist in Pseudomonas aeruginosa : An In Vivo Potent Antivirulence Agent Targeting pqs Quorum Sensing
Author(s) -
Lu Cenbin,
Maurer Christine K.,
Kirsch Benjamin,
Steinbach Anke,
Hartmann Rolf W.
Publication year - 2014
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201307547
Subject(s) - quorum sensing , pseudomonas aeruginosa , in vivo , virulence , antagonist , microbiology and biotechnology , biology , bacteria , biochemistry , receptor , gene , genetics
The virulence regulator PqsR of Pseudomonas aeruginosa is considered as an attractive target for attenuating the bacterial pathogenicity without eliciting resistance. However, despite efforts and desires, no promising PqsR antagonist has been discovered thus far. Now, a surprising functionality change of a highly affine PqsR antagonist in P. aeruginosa is revealed, which is mediated by a bacterial signal molecule synthase and responsible for low cellular potency. Blockade of the susceptible position led to the discovery of the first antivirulence compound that is potent in vivo and targets PqsR, thus providing a proof of concept for this novel antivirulence therapy.