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Mild Bioconjugation Through the Oxidative Coupling of ortho ‐Aminophenols and Anilines with Ferricyanide
Author(s) -
Obermeyer Allie C.,
Jarman John B.,
Netirojjanakul Chawita,
El Muslemany Kareem,
Francis Matthew B.
Publication year - 2014
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201307386
Subject(s) - bioconjugation , ferricyanide , chemistry , oxidative coupling of methane , combinatorial chemistry , oxidative phosphorylation , coupling (piping) , coupling reaction , organic chemistry , catalysis , biochemistry , materials science , metallurgy
Using a small‐molecule‐based screen, ferricyanide was identified as a mild and efficient oxidant for the coupling of anilines and o‐aminophenols on protein substrates. This reaction is compatible with thiols and 1,2‐diols, allowing its use in the creation of complex bioconjugates for use in biotechnology and materials applications.