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Lactose as a “Trojan Horse” for Quantum Dot Cell Transport
Author(s) -
BenitoAlifonso David,
Tremel Shirley,
Hou Bo,
Lockyear Harriet,
Mantell Judith,
Fermin David J.,
Verkade Paul,
Berry Monica,
Galan M. Carmen
Publication year - 2014
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201307232
Subject(s) - glycan , intracellular , endosome , trojan horse , chemistry , hela , quantum dot , microbiology and biotechnology , glycosylation , cell , biochemistry , biophysics , nanotechnology , biology , glycoprotein , materials science , computer security , computer science
A series of glycan‐coated quantum dots were prepared to probe the effect of glycan presentation in intracellular localization in HeLa and SV40 epithelial cells. We show that glycan density mostly impacts on cell toxicity, whereas glycan type affects the cell uptake and intracellular localization. Moreover, we show that lactose can act as a “Trojan horse” on bi‐functionalized QDs to help intracellular delivery of other non‐internalizable glycan moieties and largely avoid the endosomal/lysosomal degradative pathway.