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Covalently Coupled Immunostimulant Heterodimers
Author(s) -
Mancini Rock J.,
Tom Janine K.,
EsserKahn Aaron P.
Publication year - 2014
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201306551
Subject(s) - immunostimulant , receptor , covalent bond , chemistry , immune system , stimulation , microbiology and biotechnology , biochemistry , biophysics , biology , immunology , neuroscience , organic chemistry
We report increased stimulation of dendritic cells via heterodimers of immunostimulants formed at a discrete molecular distance. Many vaccines present spatially organized agonists to immune cell receptors. These receptors cluster suggesting that signaling is increased by spatial organization and receptor proximity, but this has not been directly tested for multiple, unique receptors. In this study we probe the spatial aspect of immune cell activation using heterodimers of two covalently attached immunostimulants.