Efficient Access to Trifluoromethyl Diarylpyrrolines and their N‐Oxides through Enantioselective Conjugate Addition of Nitromethane to β,β‐Disubstituted Enones | Zendy

Kawai Hiroyuki | Zendy; Yuan Zhe | Zendy; Kitayama Takashi | Zendy; Tokunaga Etsuko | Zendy; Shibata Norio | Zendy

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Efficient Access to Trifluoromethyl Diarylpyrrolines and their N‐Oxides through Enantioselective Conjugate Addition of Nitromethane to β,β‐Disubstituted Enones

Author(s) -

Kawai Hiroyuki,

Yuan Zhe,

Kitayama Takashi,

Tokunaga Etsuko,

Shibata Norio

Publication year - 2013

Publication title -

angewandte chemie

Language(s) - German

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.201301123

Subject(s) - nitromethane , chemistry , conjugate , enantioselective synthesis , trifluoromethyl , aryl , medicinal chemistry , stereochemistry , catalysis , organic chemistry , mathematical analysis , alkyl , mathematics

Das Cupreidinium‐Salz 1 katalysiert die enantioselektive konjugierte Addition von Nitromethan an β‐Aryl‐β‐trifluormethylarylenone ( 2 ). Die biologisch bedeutsamen chiralen Pyrroline 4 und ihre N‐Oxide 5 mit trifluormethylierten quartären C‐substituierten Stereozentren waren ausgehend von dem Schlüsselintermediat ( R )‐ 3 in guten bis ausgezeichneten Ausbeuten zugänglich.

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