Probing the Conformational Diversity of Cancer‐Associated Mutations in p53 with Ion‐Mobility Mass Spectrometry | Zendy

Jurneczko Ewa | Zendy; Cruickshank Faye | Zendy; Porrini Massimiliano | Zendy; Clarke David J. | Zendy; Campuzano Iain D. G. | Zendy; Morris Michael | Zendy; Nikolova Penka V. | Zendy; Barran Perdita E. | Zendy

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Probing the Conformational Diversity of Cancer‐Associated Mutations in p53 with Ion‐Mobility Mass Spectrometry

Author(s) -

Jurneczko Ewa,

Cruickshank Faye,

Porrini Massimiliano,

Clarke David J.,

Campuzano Iain D. G.,

Morris Michael,

Nikolova Penka V.,

Barran Perdita E.

Publication year - 2013

Publication title -

angewandte chemie

Language(s) - German

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.201210015

Subject(s) - diversity (politics) , computational biology , computer science , service (business) , chemistry , mass spectrometry , information retrieval , nanotechnology , library science , materials science , biology , sociology , chromatography , economy , anthropology , economics

Konformative Flexibilität : Die DNA‐Bindungsdomäne des Tumorsuppressorproteins p53 (siehe Bild) wird mithilfe von Ionenmobilitäts‐Massenspektrometrie charakterisiert. Wildtyp‐p53 und bekannte karzinogene Einzelpunktmutationen zeigen nach dem Transfer in das lösungsmittelfreie Umfeld eines Massenspektrometers verschiedene konformative Zustände.

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