Enzyme‐Responsive Controlled Release of Covalently Bound Prodrug from Functional Mesoporous Silica Nanospheres | Zendy

Popat Amirali | Zendy; Ross Benjamin P. | Zendy; Liu Jian | Zendy; Jambhrunkar Siddharth | Zendy; Kleitz Freddy | Zendy; Qiao Shi Zhang | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Enzyme‐Responsive Controlled Release of Covalently Bound Prodrug from Functional Mesoporous Silica Nanospheres

Author(s) -

Popat Amirali,

Ross Benjamin P.,

Liu Jian,

Jambhrunkar Siddharth,

Kleitz Freddy,

Qiao Shi Zhang

Publication year - 2012

Publication title -

angewandte chemie

Language(s) - German

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.201206416

Subject(s) - prodrug , mesoporous silica , chemistry , covalent bond , combinatorial chemistry , nanotechnology , biochemistry , organic chemistry , mesoporous material , materials science , catalysis

Enzymvermittelte Freisetzung : Die Funktionalisierung von mesoporösen SiO 2 ‐Nanopartikeln mit Sulfasalazin (SZ), einem Prodrug der 5‐Aminosalicylsäure (5‐ASA; siehe Schema) und von Sulfapyridin, ergibt enzymresponsive Nanotransporter. In Gegenwart des Kolon‐spezifischen Enzyms Azo‐Reduktase (orange) werden 5‐ASA und Sulfapyridin effizient freigesetzt.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research