Asymmetric Hydrogenation of 2,4‐Disubstituted 1,5‐Benzodiazepines Using Cationic Ruthenium Diamine Catalysts: An Unusual Achiral Counteranion Induced Reversal of Enantioselectivity | Zendy

Ding ZiYuan | Zendy; Chen Fei | Zendy; Qin Jie | Zendy; He YanMei | Zendy; Fan QingHua | Zendy

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Asymmetric Hydrogenation of 2,4‐Disubstituted 1,5‐Benzodiazepines Using Cationic Ruthenium Diamine Catalysts: An Unusual Achiral Counteranion Induced Reversal of Enantioselectivity

Author(s) -

Ding ZiYuan,

Chen Fei,

Qin Jie,

He YanMei,

Fan QingHua

Publication year - 2012

Publication title -

angewandte chemie

Language(s) - German

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.201200309

Subject(s) - chemistry , ruthenium , cationic polymerization , enantiomer , enantioselective synthesis , medicinal chemistry , catalysis , stereochemistry , organic chemistry

Die hoch enantioselektive Hydrierung von 2,4‐disubstituierten 1,5‐Benzodiazepinen mit den chiralen kationischen Ruthenium‐Diamin‐Katalysatoren ( R , R )‐ 1 (siehe Schema; BArF=Tetrakis(3,5‐bistrifluormethylphenyl)borat) kann mit einem Enantiomer des Liganden gezielt beide Enantiomere der 2,4‐Diaryl‐2,3,4,5‐tetrahydro‐1 H ‐benzodiazepin‐Produkte liefern. Entscheidend ist einzig das achirale Gegenion.

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