Membrane Anchored Immunostimulatory Oligonucleotides for In Vivo Cell Modification and Localized Immunotherapy | Zendy

Liu Haipeng | Zendy; Kwong Brandon | Zendy; Irvine Darrell J. | Zendy

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Membrane Anchored Immunostimulatory Oligonucleotides for In Vivo Cell Modification and Localized Immunotherapy

Author(s) -

Liu Haipeng,

Kwong Brandon,

Irvine Darrell J.

Publication year - 2011

Publication title -

angewandte chemie

Language(s) - German

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.201101266

Subject(s) - oligonucleotide , dna , cpg site , computational biology , chemistry , immunotherapy , rna , in vivo , microbiology and biotechnology , biochemistry , biology , immunology , gene , immune system , genetics , gene expression , dna methylation

Amphiphile Oligonucleotide , die durch kovalente Konjugation zwischen einem hydrophoben Diacyllipid und chemisch stabilisierten RNA‐ oder DNA‐Oligonucleotiden synthetisiert wurden, markieren Tumorzellen nach Injektion in feste Tumoren. In einem murinen Melanom‐Modell zeigten zellmembranverankerte CpG‐ODNs mit nukleaseresistentem Phosphorthioat‐Rückgrat (Reihe a) deutlich höhere immunstimulatorische Aktivität als lösliche CpGs (Reihe b).

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