Enantioselective Iridium‐Catalyzed Vinylogous Reformatsky‐Aldol Reaction from the Alcohol Oxidation Level: Linear Regioselectivity by Way of Carbon‐Bound Enolates | Zendy

Hassan Abbas | Zendy; Zbieg Jason R. | Zendy; Krische Michael J. | Zendy

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Enantioselective Iridium‐Catalyzed Vinylogous Reformatsky‐Aldol Reaction from the Alcohol Oxidation Level: Linear Regioselectivity by Way of Carbon‐Bound Enolates

Author(s) -

Hassan Abbas,

Zbieg Jason R.,

Krische Michael J.

Publication year - 2011

Publication title -

angewandte chemie

Language(s) - German

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.201100646

Subject(s) - enantioselective synthesis , reformatsky reaction , chemistry , aldol reaction , regioselectivity , iridium , alcohol , catalysis , organic chemistry , combinatorial chemistry , stereochemistry

Reformatsky mal anders : Hoch enantioselektive vinyloge Reformatsky‐Additionen ausgehend von der Alkohol‐ Oxidationsstufe verlaufen über kohlenstoffgebundene Enolate und liefern regioselektiv die linearen Produkte (siehe Schema; Boc= tert ‐Butoxycarbonyl). In der Reaktion eines α‐chiralen Alkohols bewirkt der Katalysator eine vollständige Diastereoselektivität.

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