Attomolar Detection of a Cancer Biomarker Protein in Serum by Surface Plasmon Resonance Using Superparamagnetic Particle Labels | Zendy

Krishnan Sadagopan | Zendy; Mani Vigneshwaran | Zendy; Wasalathanthri Dhanuka | Zendy; Kumar Challa V. | Zendy; Rusling James F. | Zendy

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Attomolar Detection of a Cancer Biomarker Protein in Serum by Surface Plasmon Resonance Using Superparamagnetic Particle Labels

Author(s) -

Krishnan Sadagopan,

Mani Vigneshwaran,

Wasalathanthri Dhanuka,

Kumar Challa V.,

Rusling James F.

Publication year - 2011

Publication title -

angewandte chemie

Language(s) - German

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.201005607

Subject(s) - surface plasmon resonance , nanotechnology , chemistry , superparamagnetism , biomarker , particle (ecology) , chromatography , materials science , physics , nanoparticle , biochemistry , biology , magnetization , quantum mechanics , magnetic field , ecology

Signalverstärker : Superparamagnetische Partikel‐Antikörper‐Konjugate ermöglichten den Nachweis eines Krebs‐Biomarkers in Serum durch Oberflächenplasmonenresonanz (SPR) in einer beispiellos niedrigen Konzentration von 10 fg mL −1 (ca. 300 a M ). Die ultrahohe Empfindlichkeit resultiert aus der zusätzlichen Masse und dem höheren Brechungsindex von Aggregaten 1 μm großer magnetischer Partikel (MPs) auf dem SPR‐Chip.

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