Selective Detection of 5‐Formyl‐2′‐deoxyuridine, an Oxidative Lesion of Thymidine, in DNA by a Fluorogenic Reagent | Zendy

Hirose Wataru | Zendy; Sato Kousuke | Zendy; Matsuda Akira | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Selective Detection of 5‐Formyl‐2′‐deoxyuridine, an Oxidative Lesion of Thymidine, in DNA by a Fluorogenic Reagent

Author(s) -

Hirose Wataru,

Sato Kousuke,

Matsuda Akira

Publication year - 2010

Publication title -

angewandte chemie

Language(s) - German

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.201004087

Subject(s) - chemistry , reagent , dna , deoxyuridine , thymidine , microbiology and biotechnology , high performance liquid chromatography , oxidative phosphorylation , biochemistry , chromatography , organic chemistry , biology

Chemoselektivität in DNA : Die Thymidin‐Läsion 5‐Formyl‐2′‐desoxyuridin ( 1 ) induziert eine DNA‐Mutation. Ihre Derivatisierung mit dem spezifischen fluorogenen Reagens 2‐Amino‐4,5‐dimethoxybenzolthiol ( 2 ) ergibt die stark fluoreszierende Spezies 3. Dieser schnelle Nachweis von 1 kommt ohne Enzymverdau, HPLC‐Trennung und MS‐Analyse aus. ROS=reaktive Sauerstoffspezies.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research