Reaction of 2‐(2,2,2‐Trifluoroethylidene)‐1,3‐dithiane 1‐Oxide with Ketones under Pummerer Conditions and Its Application to the Synthesis of 3‐Trifluoromethyl‐Substituted Five‐Membered Heteroarenes | Zendy

Kobatake Takayuki | Zendy; Yoshida Suguru | Zendy; Yorimitsu Hideki | Zendy; Oshima Koichiro | Zendy

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Reaction of 2‐(2,2,2‐Trifluoroethylidene)‐1,3‐dithiane 1‐Oxide with Ketones under Pummerer Conditions and Its Application to the Synthesis of 3‐Trifluoromethyl‐Substituted Five‐Membered Heteroarenes

Author(s) -

Kobatake Takayuki,

Yoshida Suguru,

Yorimitsu Hideki,

Oshima Koichiro

Publication year - 2010

Publication title -

angewandte chemie

Language(s) - German

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.200906774

Subject(s) - chemistry , dithiane , trifluoromethyl , oxide , schema (genetic algorithms) , medicinal chemistry , polymer chemistry , organic chemistry , computer science , machine learning , alkyl

Kinderleicht : Triflatanhydrid ermöglichte die Titelreaktion, die aus dem nucleophilen Angriff des Carbonylsauerstoffatoms auf das aktivierte kationische Schwefelzentrum und einer [3,3]‐sigmatropen Umlagerung besteht (siehe Schema). Die Produkte sind Vorstufen für die schwierig herzustellenden fünfgliedrigen 3‐Trifluormethylheteroarene.

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