Enantioselective Gold‐Catalyzed Allylic Alkylation of Indoles with Alcohols: An Efficient Route to Functionalized Tetrahydrocarbazoles | Zendy

Bandini Marco | Zendy; Eichholzer Astrid | Zendy

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Enantioselective Gold‐Catalyzed Allylic Alkylation of Indoles with Alcohols: An Efficient Route to Functionalized Tetrahydrocarbazoles

Author(s) -

Bandini Marco,

Eichholzer Astrid

Publication year - 2009

Publication title -

angewandte chemie

Language(s) - German

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.200904388

Subject(s) - enantioselective synthesis , friedel–crafts reaction , chemistry , allylic rearrangement , tsuji–trost reaction , catalysis , alkylation , intramolecular force , stereochemistry , combinatorial chemistry , organic chemistry

Ein Tabu gebrochen : Die erste erfolgreiche direkte Verwendung von Allylalkoholen in katalytischen und enantioselektiven Friedel‐Crafts‐Alkylierungen gelang in Gegenwart chiraler Goldkomplexe. Diese intramolekulare Friedel‐Crafts‐Reaktion machte eine Vielzahl an funktionalisierten Tetrahydrocarbazolen zugänglich (siehe Schema; X=Me, F, Br, Cl, OMe; R=Me, Et, t Bu; R′=H, Me).

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