Direct  anti ‐Selective Catalytic Asymmetric Mannich‐Type Reactions of α‐Ketoanilides for the Synthesis of γ‐Amino Amides and Azetidine‐2‐amides | Zendy

Xu Yingjie | Zendy; Lu Gang | Zendy; Matsunaga Shigeki | Zendy; Shibasaki Masakatsu | Zendy

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Direct anti ‐Selective Catalytic Asymmetric Mannich‐Type Reactions of α‐Ketoanilides for the Synthesis of γ‐Amino Amides and Azetidine‐2‐amides

Author(s) -

Xu Yingjie,

Lu Gang,

Matsunaga Shigeki,

Shibasaki Masakatsu

Publication year - 2009

Publication title -

angewandte chemie

Language(s) - German

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.200900670

Subject(s) - amide , azetidine , chemistry , catalysis , mannich reaction , stereochemistry , medicinal chemistry , combinatorial chemistry , organic chemistry

Mannich 'mal anders : Der Dinickelkomplex einer Biphenyldiamin‐Schiff‐Base katalysiert die anti ‐selektive Mannich‐Reaktion von α‐Ketoaniliden (siehe Schema), die als nützliche Synthesebausteine für Azetidin‐2‐amide und α‐Hydroxy‐γ‐aminoamide fungieren. Dieser Ansatz ergänzt konventionelle Mannich‐Reaktionen, die β‐Aminocarbonylverbindungen ergeben. o ‐Ns= o ‐Nitrobenzolsulfonyl.

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