Stereocontrolled Solid‐Phase Synthesis of Oligonucleoside  H ‐Phosphonates by an Oxazaphospholidine Approach | Zendy

Iwamoto Naoki | Zendy; Oka Natsuhisa | Zendy; Sato Terutoshi | Zendy; Wada Takeshi | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Stereocontrolled Solid‐Phase Synthesis of Oligonucleoside H ‐Phosphonates by an Oxazaphospholidine Approach

Author(s) -

Iwamoto Naoki,

Oka Natsuhisa,

Sato Terutoshi,

Wada Takeshi

Publication year - 2009

Publication title -

angewandte chemie

Language(s) - German

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.200804408

Subject(s) - phosphonate , chemistry , solid phase synthesis , stereochemistry , schema (genetic algorithms) , combinatorial chemistry , computer science , organic chemistry , information retrieval , biochemistry , peptide

Stereodefinierte Oligonucleosid‐ H ‐phosphonate wurden aus diastereomerenreinen Nucleosid‐3′‐ O ‐oxazaphospholidin‐Monomeren an einem festen Träger synthetisiert. Diese Oligonucleosid‐ H ‐phosphonate ließen sich in eine ganze Reihe von stereodefinierten rückgratmodifizierten Analoga überführen (siehe Schema; B PRO =geschützte Nucleobase, DMTr=4,4′‐Dimethoxytrityl, Th=Thymin‐1‐yl, TfO − =Triflat).

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research