Tuning the Basicity of Synergic Bimetallic Reagents: Switching the Regioselectivity of the Direct Dimetalation of Toluene from 2,5‐ to 3,5‐Positions | Zendy

Blair Victoria L. | Zendy; Carrella Luca M. | Zendy; Clegg William | Zendy; Conway Ben | Zendy; Harrington Ross W. | Zendy; Hogg Lorna M. | Zendy; Klett Jan | Zendy; Mulvey Robert E. | Zendy; Rentschler Eva | Zendy; Russo Luca | Zendy

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Tuning the Basicity of Synergic Bimetallic Reagents: Switching the Regioselectivity of the Direct Dimetalation of Toluene from 2,5‐ to 3,5‐Positions

Author(s) -

Blair Victoria L.,

Carrella Luca M.,

Clegg William,

Conway Ben,

Harrington Ross W.,

Hogg Lorna M.,

Klett Jan,

Mulvey Robert E.,

Rentschler Eva,

Russo Luca

Publication year - 2008

Publication title -

angewandte chemie

Language(s) - German

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.200801158

Subject(s) - regioselectivity , toluene , chemistry , bimetallic strip , reagent , stereochemistry , combinatorial chemistry , organic chemistry , catalysis

Meta ‐ , Meta‐ , Metallierung ! Toluol kann durch Dimetallbasen mit aktiven Me 3 SiCH 2 ‐Liganden direkt an der 3‐ und 5‐Position dimanganiert oder dimagnesiert werden (siehe Schema, blau). Dagegen resultieren n ‐Butylliganden in einer 2,5‐Metallierung (rot). tmp=2,2,6,6‐Tetramethylpiperidid.

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