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Highly Enantioselective and Diastereoselective Cycloaddition of Cyclopropanes with Nitrones and Its Application in the Kinetic Resolution of 2‐Substituted Cyclopropane‐1,1‐dicarboxylates
Author(s) -
Kang YanBiao,
Sun XiuLi,
Tang Yong
Publication year - 2007
Publication title -
angewandte chemie
Language(s) - German
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.200604645
Subject(s) - cycloaddition , enantioselective synthesis , cyclopropane , chemistry , kinetic resolution , aryl , stereochemistry , medicinal chemistry , organic chemistry , catalysis , ring (chemistry) , alkyl
Ein Multitalent ist der Katalysator Ni(ClO 4 ) 2 / 1 , der beide Titelprozesse vermittelt (siehe Schema). Gemeinsam eröffnen die effiziente asymmetrische Cycloaddition und eine kinetische Racematspaltung/Cycloaddition den Zugang zu beiden Enantiomeren von Tetrahydro‐1,2‐oxazinen. DME=1,2‐Dimethoxyethan; R 1 =Aryl, Vinyl; R 2 =Et, Me, Benzyl; R 3 =Me, Ph; R 4 =Aryl, Styryl.