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De Novo Design and Synthesis of Helix–Turn–Helix Structure from Short and Robust Mixed Helices Derived from C‐Linked Carbo‐β‐Amino Acids
Author(s) -
Sharma Gangavaram V. M.,
Subash Velaparthi,
Narsimulu Kongari,
Sankar Ampapathi Ravi,
Kunwar Ajit C.
Publication year - 2006
Publication title -
angewandte chemie
Language(s) - German
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.200603084
Subject(s) - helix (gastropod) , triple helix , chemistry , stereochemistry , turn (biochemistry) , helix turn helix , crystallography , biochemistry , biology , dna binding protein , ecology , snail , gene , transcription factor
Abgeknickt : Durch Anbringen von kurzen Peptiden mit robusten gemischten 10/12‐Helices aus C‐verknüpften Carbo‐β‐aminosäuren an die schleifeninduzierende Gruppe β‐hGly‐ D ‐Pro‐Gly‐β‐hGly gelang das De‐novo‐Design eines Helix‐Schleife‐Helix‐Motivs in der Foldamerdomäne.