Azumamides A–E: Histone Deacetylase Inhibitory Cyclic Tetrapeptides from the Marine Sponge  Mycale izuensis | Zendy

Nakao Yoichi | Zendy; Yoshida Satoru | Zendy; Matsunaga Shigeki | Zendy; Shindoh Nobuaki | Zendy; Terada Yoh | Zendy; Nagai Koji | Zendy; Yamashita Jun K. | Zendy; Ganesan A. | Zendy; van Soest Rob W. M. | Zendy; Fusetani Nobuhiro | Zendy

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Azumamides A–E: Histone Deacetylase Inhibitory Cyclic Tetrapeptides from the Marine Sponge Mycale izuensis

Author(s) -

Nakao Yoichi,

Yoshida Satoru,

Matsunaga Shigeki,

Shindoh Nobuaki,

Terada Yoh,

Nagai Koji,

Yamashita Jun K.,

Ganesan A.,

van Soest Rob W. M.,

Fusetani Nobuhiro

Publication year - 2006

Publication title -

angewandte chemie

Language(s) - German

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.200602047

Subject(s) - tetrapeptide , sponge , chemistry , histone deacetylase , stereochemistry , inhibitory postsynaptic potential , histone , peptide , biochemistry , biology , botany , neuroscience , gene

Azumamide unter der Lupe (1) : Fünf neue cyclische Tetrapeptide, die Azumamide A–E, wurden aus dem Meeresschwamm Mycale izuensis isoliert. Sie inhibieren die Histon‐Desacetylase mit IC 50 ‐Werten von 0.045 bis 1.3 μg mL −1 . Ihre Strukturen wurden anhand von spektroskopischen Analysen und chemischen Abbaustudien ermittelt.

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