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Directed Evolution of Enantioselective Enzymes: Iterative Cycles of CASTing for Probing Protein‐Sequence Space
Author(s) -
Reetz Manfred T.,
Wang LiWen,
Bocola Marco
Publication year - 2006
Publication title -
angewandte chemie
Language(s) - German
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.200502746
Subject(s) - directed evolution , sequence (biology) , enantioselective synthesis , sequence space , chemistry , casting , enzyme , saturation (graph theory) , combinatorial chemistry , materials science , biochemistry , mathematics , combinatorics , metallurgy , mutant , pure mathematics , banach space , gene , catalysis
Umbaumaßnahmen am Enzym : Der jüngst eingeführte CAST (=combinatorial active‐site saturation test) wurde in Iterationszyklen bei der gerichteten Evolution enantioselektiver Wildtyp‐Epoxidhydrolasen (WT‐EH) angewendet.
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