Regio‐ and Chemoselective 6′‐N‐Derivatization of Aminoglycosides: Bisubstrate Inhibitors as Probes To Study Aminoglycoside 6′‐ N ‐Acetyltransferases | Zendy

Gao Feng | Zendy; Yan Xuxu | Zendy; Baettig Oliver M. | Zendy; Berghuis Albert M. | Zendy; Auclair Karine | Zendy

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Regio‐ and Chemoselective 6′‐N‐Derivatization of Aminoglycosides: Bisubstrate Inhibitors as Probes To Study Aminoglycoside 6′‐ N ‐Acetyltransferases

Author(s) -

Gao Feng,

Yan Xuxu,

Baettig Oliver M.,

Berghuis Albert M.,

Auclair Karine

Publication year - 2005

Publication title -

angewandte chemie

Language(s) - German

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.200501399

Subject(s) - acetyltransferases , chemistry , derivatization , acetyltransferase , stereochemistry , acetylation , biochemistry , organic chemistry , high performance liquid chromatography , gene

Einfach zu komplexen nanomolaren Inhibitoren : Aminoglycosid‐Coenzym‐A‐Derivate wurden durch eine effiziente regioselektive 6′‐N‐Modifizierung von Aminoglycosiden hergestellt (siehe Schema). Diese Bisubstrate sind fest bindende kompetitive Inhibitoren der Aminoglycosid‐6′‐ N ‐Acetyltransferase, eines an der Antibiotikaresistenz beteiligten Enzyms.

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