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Asymmetric Synthesis of Diarylmethyl Amines by Rhodium‐Catalyzed Asymmetric Addition of Aryl Titanium Reagents to Imines
Author(s) -
Hayashi Tamio,
Kawai Masahiro,
Tokunaga Norihito
Publication year - 2004
Publication title -
angewandte chemie
Language(s) - German
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.200461338
Subject(s) - chemistry , aryl , reagent , catalysis , rhodium , enantioselective synthesis , medicinal chemistry , organic chemistry , alkyl
Rationales Justieren der Arensulfonamid‐Einheit (durch das Einführen von Isopropylgruppen) bewirkte eine hohe Enantioselektivität in der asymmetrischen Synthese von (Diarylmethyl)aminen durch die Titelreaktion (siehe Schema). Ar 1 =4‐CF 3 C 6 H 4 , 4‐ClC 6 H 4 , 4‐FC 6 H 4 , 3‐MeOC 6 H 4 , 4‐MeOC 6 H 4 , 2‐MeC 6 H 4 , 1‐Naphthyl, Ph; Ar 2 =Ph, 4‐FC 6 H 4 , 3‐MeOC 6 H 4 , 4‐MeOC 6 H 4 .
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