Open AccessMorphology‐Dependent Bioadhesion and Bioelimination of Hyaluronan Particles Administered in the Bladder
Author(s) -
Diaz-Salmeron Raul,
Toussaint Balthazar,
Cailleau Catherine,
Ponchel Gilles,
Bouchemal Kawthar
Publication year - 2022
Publication title -
advanced nanobiomed research
Language(s) - English
Resource type - Journals
ISSN - 2699-9307
DOI - 10.1002/anbr.202270051
Subject(s) - hyaluronic acid , morphology (biology) , in vivo , drug delivery , ex vivo , particle (ecology) , biomedical engineering , chemistry , biophysics , human bladder , materials science , nanotechnology , in vitro , anatomy , bladder cancer , medicine , biochemistry , biology , ecology , genetics , microbiology and biotechnology , cancer
Bioadhesion In article number 2100138 , Kawthar Bouchemal and co‐workers demonstrate that the flat morphology of hyaluronan particles significantly improves bioadhesion and decreases bioelimination from the bladder. Bioadhesion kinetics are evaluated ex vivo on rat bladder mucosa, while particle bioelimination is studied in vivo using a real‐time imager system. This investigation could open opportunities for efficient drug delivery.