Open AccessA Biomicrofluidic Screening Platform for Dysfunctional Endothelium‐Targeted Nanoparticles and Therapeutics
Author(s) -
Bazban-Shotorbani Salime,
Gavins Felicity,
Kant Krishna,
Dufva Martin,
Kamaly Nazila
Publication year - 2022
Publication title -
advanced nanobiomed research
Language(s) - English
Resource type - Journals
ISSN - 2699-9307
DOI - 10.1002/anbr.202270011
Subject(s) - dysfunctional family , nanoparticle , nanotechnology , mediator , inflammation , endothelium , computer science , materials science , medicine , microbiology and biotechnology , psychology , biology , immunology , psychotherapist
Biomicrofluidic Models Biomicrofluidic models allow nanoparticle‐cellular interactions to be studied under physiological flow conditions. Investigating nanoparticle biophysicochemical properties in models that resemble disease can provide valuable information about the nano‐bio interface. By screening nanoparticles dynamically against a developed dysfunctional‐endothelium‐on chip model, Nazila Kamaly and co‐workers show in article number 2100092 that nanoparticle size is a dominant factor beyond targeting ligands. Furthermore, tight junction disruption can be restored by the inflammation resolving mediator Annexin A1.