Open AccessRotavirus Binding to Cell Surface Receptors Directly Recruiting α 2 Integrin
Author(s) -
Yang Jinsung,
Park Jeongsoo,
Koehler Melanie,
Simpson Joshua,
Luque Daniel,
Rodríguez Javier M.,
Alsteens David
Publication year - 2021
Publication title -
advanced nanobiomed research
Language(s) - English
Resource type - Journals
ISSN - 2699-9307
DOI - 10.1002/anbr.202170123
Subject(s) - internalization , rotavirus , integrin , clathrin , receptor , endocytosis , confocal microscopy , microbiology and biotechnology , atomic force microscopy , viral entry , cell , confocal , virology , receptor mediated endocytosis , chemistry , virus , biology , nanotechnology , materials science , biochemistry , viral replication , physics , optics
Virus–Receptor Interactions In article number 2100077 , David Alsteens and co‐workers report that Rotavirus binding and early entry is mediated by an integrin on the cell surface. The binding is assessed by Atomic Force Microscopy, while recruitment of internalization machinery is monitored by confocal imaging. The interaction between rotavirus VP8* and CHO cell α 2 β 1 integrins induces clathrin pit formation, contributing to successful viral infection.