Open AccessIntegrated Perspective of Scaffold Designing and Multiscale Mechanics in Cardiac Bioengineering
Author(s) -
Lou Lihua,
Lopez Kazue Orikasa,
Nautiyal Pranjal,
Agarwal Arvind
Publication year - 2021
Publication title -
advanced nanobiomed research
Language(s) - English
Resource type - Journals
ISSN - 2699-9307
DOI - 10.1002/anbr.202100075
Subject(s) - scaffold , tissue engineering , function (biology) , cell mechanics , computer science , biochemical engineering , nanotechnology , regenerative medicine , perspective (graphical) , biomedical engineering , engineering , materials science , chemistry , stem cell , artificial intelligence , biology , microbiology and biotechnology , cell , biochemistry , cytoskeleton
Although progress has been made, a fully functional and transplantable cardiac patch is elusive due to several challenges. These challenges emanate from a nonoptimal understanding of different fields and expertise in biomedical, material, tissue, medicine, chemistry, biology, and mechanical engineering. Therefore, herein, an integrated approach for scaffold design requirements is critically reviewed. The scaffold manufacturing methods and prospects of electrical and mechanical stimulation to promote the maturation and function of cardiac tissues are presented. The mechanical behavior of cardiac cells and tissue functions are a fundamental requirement for a functional patch. Methods, data analysis, and mathematic models for measuring and quantifying cellular and tissue mechanics are discussed. Overall, this article serves as an overview, indicating the need for an “integrated” and collaborative approach to designing and fabricating functional and implantable cardiac tissues.