Open AccessReshaping the Inflammatory Environment in Rheumatoid Arthritis Joints by Targeting Delivery of Berberine with Platelet‐Derived Extracellular Vesicles
Author(s) -
Ma Qingle,
Bai Jinyu,
Xu Jialu,
Dai Huaxing,
Fan Qin,
Fei Ziying,
Chu Jiacheng,
Yao Chenlu,
Shi Haoliang,
Zhou Xiaozhong,
Bo Lin,
Wang Chao
Publication year - 2021
Publication title -
advanced nanobiomed research
Language(s) - English
Resource type - Journals
ISSN - 2699-9307
DOI - 10.1002/anbr.202100071
Subject(s) - rheumatoid arthritis , inflammation , berberine , platelet , medicine , arthritis , drug delivery , extracellular vesicles , extracellular , pharmacology , immunology , chemistry , microbiology and biotechnology , biochemistry , biology , organic chemistry
Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by inflammation and joint destruction. Herein, an inflamed joint‐targeting delivery platform is developed based on platelet‐derived extracellular vesicles (PEVs) that are naturally occurring nanoparticles released by platelets, loaded with berberine (BBR) for suppressing the progress of RA. It is found that PEVs could selectively target the inflamed arthritis site in RA mice. In addition, BBR‐loaded PEVs exert anti‐inflammatory effects by reshaping the inflammatory environment in affected joints. It is shown that intravenous injection of BBR‐loaded PEVs into RA mice can effectively reduce joint swelling and bone erosion and restore mobility compared with free drug therapy. This strategy can effectively enhance the efficacy of RA treatment with limited side effects.