Open AccessCancer Stem Cells in Tumor Modeling: Challenges and Future Directions
Author(s) -
Dogan Elvan,
Kisim Asli,
Bati-Ayaz Gizem,
Kubicek Gregory J.,
Pesen-Okvur Devrim,
Miri Amir K.
Publication year - 2021
Publication title -
advanced nanobiomed research
Language(s) - English
Resource type - Journals
ISSN - 2699-9307
DOI - 10.1002/anbr.202100017
Subject(s) - cancer stem cell , tumor microenvironment , cancer , cancer cell , cancer research , organoid , tumor cells , stem cell , biology , medicine , neuroscience , microbiology and biotechnology
Microfluidic tumors‐on‐chips models have revolutionized anticancer therapeutic research by creating an ideal microenvironment for cancer cells. The tumor microenvironment (TME) includes various cell types and cancer stem cells (CSCs), which are postulated to regulate the growth, invasion, and migratory behavior of tumor cells. In this review, the biological niches of the TME and cancer cell behavior focusing on the behavior of CSCs are summarized. Conventional cancer models such as 3D cultures and organoid models are reviewed. Opportunities for the incorporation of CSCs with tumors‐on‐chips are then discussed for creating tumor invasion models. Such models will represent a paradigm shift in the cancer community by allowing oncologists and clinicians to predict better which cancer patients will benefit from chemotherapy treatments.