Open AccessArtificial Engineering of Immune Cells for Improved Immunotherapy
Author(s) -
Li Chuxin,
Qi Yongdan,
Zhang Yu,
Chen Yingge,
Feng Jun,
Zhang Xianzheng
Publication year - 2021
Publication title -
advanced nanobiomed research
Language(s) - English
Resource type - Journals
ISSN - 2699-9307
DOI - 10.1002/anbr.202000081
Subject(s) - immune system , immunotherapy , innate immune system , immunology , macrophage , disease , medicine , biology , biochemistry , pathology , in vitro
An immune system is of vital importance for maintaining the host health. Taking advantage of innate merits of immune cells, cell‐based immunotherapy has demonstrated great potentials for treating many severe diseases, especially for cancers and inflammatory diseases. However, the success of this promising therapy modality suffers from complex and immunosuppressive conditions generated along with disease development. The combination among cellular biology, nanotechnology, and material science offers vast opportunities to improve therapeutic efficacy and expand function. This review introduces recent advance in exploiting nanotechnology and materials to initiate and reinforce therapeutic functions of live immune cells, including monocyte, macrophage, dendritic cell, and T lymphocytes. The major strategies in artificially engineered cell immunotherapy are briefly summarized, and the possible developing trend in this field is discussed.